Intervertebral disc degeneration(IDD)is an age-related degenerative disease of the spine that has a significant impact on socioeconomic and human life.The pathogenesis of IDD is complex and current treatments are ineffective,so there is an urgent need to find new therapeutic targets.Long non-coding RNA(lncRNA)is a kind of RNA with more than 200 nucleotides and no coding function,which is involved in cell proliferation,apoptosis,and senescence,regulating the progression of several types of diseases.In recent years,a large number of studies have confirmed that lncRNA affects gene expression in IDD through signaling pathways such as Wnt/β-catenin,PI3K/Akt,and MAPK,etc.Therefore,this paper provides an overview of the molecular mechanism of lncRNA regulation of IDD through signaling pathways,aiming to provide new therapeutic targets for the treatment of IDD.
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