Role of lncRNA-miRNA axis in colorectal cancer progression and therapy resistance
Epigenetic factors are key regulators of biological and pathological mechanisms,and they can interact with different molecular pathways.As epigenetic factors,long non-coding RNA(lncRNA)play a role in promoting or suppressing colorectal cancer(CRC)by targeting microRNA(miRNA)and related signaling pathways.Therefore,it is of great value to clarify the lncRNA-miRNA axis according to the specific lncRNA/miRNA interactions for the diagnosis,prognosis and precise targeting strategy of CRC.This article summarizes and discusses the role and mechanism of lncRNA-miRNA axis in the proliferation,metastasis,invasion and therapy resistance of CRC.
long non-coding RNAmicroRNAcolorectal cancermechanismchemoresistanceradio-resistance
万方数据
维普
