FYVE domain-containing phosphatidylinositol 3-phosphate 5-kinase(PIKfyve)is a phosphati-dylinositol lipid kinase in mammalian that produces phosphatidylinositol-3,5-bisphosphate[PtdIns(3,5)P2]or phosphatidylinositol-5-phosphate[PtdIns(5)P]by catalyzing phosphatidylinositol-3-phosphate[PtdIns(3)P].It plays a critical role in regulating membrane transport and maintaining lysosomal function,and is also involved in intracellular transport,transcriptional regulation,and immune regulation,among many other important cellular biological functions.Recent studies have shown that PIKfyve plays an important role in inflammation,pathogenic microbial infections,neurodegenerative diseases,and tumor development,makes it a potential target for disease prevention and treatment.This paper reviews the biochemical characteristics of PIKfyve,its biological functions and its role in related diseases.
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