Research progress on the effect and mechanism of hydrogen sulfide on vascular remodeling
Hydrogen sulfide(H2S)is considered to be a colorless toxic gas with a rotten egg odor that can cause damage to a variety of tissues and organs when inhaled in large quantities and can lead to death.However,recent studies have shown that H2S has a variety of physiological and pathological regulatory effects in the cardiovascular system,and is the third gas signaling molecule in the regulation of cardiovascular function,which is mainly enzymatically promoted and regulated by a variety of metabolic pathways.As a physiological vascular regulatory factor,H2S can inhibit vascular cell proliferation,apoptosis,and autophagy,and regulate vascular tension.A large number of studies have shown that the downregulation of the H2S pathway is involved in the pathogenesis of a variety of vascular diseases,such as hypertension,pulmonary hypertension,atherosclerosis,etc.In addition,H2S supplementation can regulate vascular tension,inhibit vascular inflammation,prevent vascular cell calcification,oxidative stress,and proliferation,and regulate vascular cell apoptosis and pyrodeath,thus greatly help to prevent and treat vascular diseases.This conclusion has been verified in animal and cell experiments and even clinical studies.This paper mainly discusses the role and mechanism of H2S in vascular physiology and pathophysiology,aiming to provide new ideas and inspiration for the prevention and treatment of various vascular diseases.
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