Research progress of mycobacterial membrane protein-related anti-tuberculosis drug targets
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis.It is of great significance in the development of anti-tuberculosis drugs based on new targets.Mycobacterial membrane proteins,which embed in or bound to the phospholipid bilayer of cell membranes,participate in important physiological functions such as cell synthesis,molecular trans-membrane transport and catalysis,as well as pathogenic mechanisms such as immune recognition,immune escape and virulence factors release in host infections.In addition,membrane proteins have better drug accessibility due to the specific topological structures and cellular localization.Therefore,mycobacterial membrane proteins are ideal potential targets of anti-tuberculosis drugs.In this review,we will summarize the research progresses of mycobacterial membrane proteins in cell wall synthesis,molecular trans-membrane transport,bacterial dormancy,bacteria-host interaction and secretion system.This review will provide new ideas for the development of anti-tuberculosis drugs.
mycobacteriamembrane proteinanti-tuberculosis drug target
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