As a tumor suppressor,p53 can coordinate a variety of reactions,including cell cycle arrest,DNA repair,anti-oxidation,anti-angiogenesis,autophagy,senescence and apoptosis.p53 exerts its tumor suppressor function mainly by regulating the transcription of its target genes.However,p53 is one of the most common mutant genes in cancer.When p53 mutates,it will lead to the loss of its function and lead to the growth of tumor cells.It has become one of the most important and attractive drug targets in cancer treatment.Therefore,many cancer treatment methods are produced by targeting p53.This article reviews the research of targeted p53 signaling pathway in gene therapy,targeted therapy and immunotherapy,in order to provide new ideas for understanding the research of targeting p53.
维普
万方数据
