The interaction of intestinal microbiotas and endogenous cannabinoid system in rheumatoid arthritis
Rheumatoid arthritis(RA)is a repetitive ictal chronic disease,which easily leads to joint deformity.Thus,the daily life quality of the patients should be affected.RA pathogenesis mainly included the interaction of gut microbial dysbiosis,short-chain fatty acid(SCFA),endogenous cannabinoid system(ECS)and inflammatory reaction.This work reviewed the interaction of gut microbiotas,SCFA and ECS based on the theories of microbiota-gut-joint axis,and introduce the research progress of RA intervene strategies,in order to provide new insight for new drug development mechanism related to RA treatment.
gut microbiotasshort-chain fatty acidendogenous cannabinoid systemrheumatoid arthritiscannabinoid receptor
万方数据
维普
