Rheumatoid arthritis(RA)is a repetitive ictal chronic disease,which easily leads to joint deformity.Thus,the daily life quality of the patients should be affected.RA pathogenesis mainly included the interaction of gut microbial dysbiosis,short-chain fatty acid(SCFA),endogenous cannabinoid system(ECS)and inflammatory reaction.This work reviewed the interaction of gut microbiotas,SCFA and ECS based on the theories of microbiota-gut-joint axis,and introduce the research progress of RA intervene strategies,in order to provide new insight for new drug development mechanism related to RA treatment.
关键词
肠道微生态/短链脂肪酸/内源性大麻素系统/类风湿性关节炎/大麻素受体
Key words
gut microbiotas/short-chain fatty acid/endogenous cannabinoid system/rheumatoid arthritis/cannabinoid receptor
维普
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