Research progress on miRNA regulation of IGFBPs involved in tumorigenesis
As a class of RNA molecules widely existing in eukaryotic cells,microRNA plays an irreplaceable and important role in the regulation of gene expression,growth and development and other basic life processes in organisms,which is closely related to human diseases.Insulin-like growth factor binding proteins(IGFBPs)is a class of proteins that binds to insulin-like growth factor(IGF)and is involved in the regulation of IGF.It plays an important role in tumors through IGF-dependent or non-IGF-dependent mechanisms.The abnormal expression of IGFBPs and miRNA in tumors is closely related to the proliferation,invasion and metastasis of tumor cells.IGFBPs act as direct target genes or downstream signaling molecules of miRNAs and are involved in the development and progression of various diseases.This review summarizes the regulatory effects of miRNA on IGFBPs in various of neoplastic diseases such as brain,gastrointestinal tract,hepatobiliary,and gynecological diseases,with a view to providing a comprehensive and professional reference for the exploration of clinical diagnosis,prognostic biomarkers,or therapeutic targets for related diseases.
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维普
