Mechanism of NF-κB participating in the occurrence and development of Crohn's disease
The incidence rate of Crohn's disease is increasing in recent years.Nuclear factor-kappa B(NF-κB)is involved in regulating immunity,inflammatory response and intestinal homeostasis.Its abnormal activation is an important risk factor for inducing or aggravating Crohn's disease.Abnormal activated NF-κB changes the functional status of immune cells and intestinal epithelial cells,and then induces chronic persistent intestinal inflammation and damages the intestinal mucosal barrier.Understand the relationship between NF-κB and Crohn's disease can provide valuable ideas for the prevention and treatment of Crohn's disease.This paper reviews NF-κB,activation pathway of NF-κB,the mechanism that NF-κB induces Crohn's disease by regulating the function of intestinal epithelial cells,T helper cell differentiation,macrophage polarization,neutrophil apoptosis and dendritic cell maturation,and the role of NF-κB in ulcerative colitis.
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