囊泡分选蛋白35(vacuolar protein sorting 35,VPS35)是一种逆转运蛋白,负责货物蛋白的分选和运输,与阿尔茨海默病、帕金森病等神经退行性疾病有关.VPS35广泛参与多种信号通路,在细胞的生长、增殖、自噬和凋亡等方面具有重要的作用.VPS35在多种恶性肿瘤中高表达,并通过不同机制调节肿瘤细胞的增殖、迁移、侵袭能力.本文主要围绕VPS35的结构特征、参与的信号通路及VPS35在恶性肿瘤中发挥的作用进行综述,旨在为今后的临床研究提供理论依据.
Roles of VPS35 in malignant tumors
Vacuolar protein sorting 35(VPS35)is a reverse transport protein,responsible for the sorting and transport of cargo proteins,which is related to neurodegenerative diseases such as Alzheimerʼs disease and Parkinsonʼs disease.VPS35 is widely involved in a variety of signaling pathways and plays an important role in cell growth,proliferation,autophagy and apoptosis.In recent years,a large number of studies have shown that VPS35 is expressed in a variety of malignant tumors and regulates the proliferation,migration and invasion ability of tumor cells through different mechanisms.This work mainly focuses on the structural characteristics of VPS35,the involved signaling pathways and the role of VPS35 in malignant tumors,aiming to provide a theoretical basis for future clinical research.
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