The effects and mechanisms of endogenous sulfur dioxide on myocardial injury
Sulfur dioxide,an acidic gas with a strong pungent smell,used to be considered harmful.Endogenous SO2 is the fourth gas signaling molecule after nitric oxide,carbon monoxide and hydrogen sulfide.It can be produced endogenously in cardiovascular tissues and plays an important physiological and pathophysiological role in the regulation of cardiovascular system.SO2 has a dose-dependent negative inotropic effect on cardiac function,in which adenosine triphosphate sensitive potassium channels are involved.SO2 can also reduce myocardial injury caused by various harmful stimuli,and play an important role in myocardial ischemia-reperfusion injury and myocardial hypertrophy.The mechanism of action is related to the inhibition of inflammation and antioxidant effects of SO2.In addition,SO2 can inhibit the apoptosis and autophagy of cardiomyocytes.Therefore,endogenous SO2 plays an important role in maintaining the homeostasis of the cardiovascular system.This review focuses on endogenous SO2 production and metabolism,cardiovascular biological effects and myocardial protective mechanisms mediated by endogenous SO2/aspartate aminotransferase system.
万方数据
维普
