β-arrestin2 is a kind of intracellular protein with multiple biological functions.It can not only negatively regulate GPCR signal pathway by competitively binding to G protein-coupled receptor(GPCR)with G protein,but also participate in regulating multiple signal transduction pathways through G protein independent pathways,which is critical to the stability of cardiovascular system.In addition,the abnormal expression of β-arrestin2 is associated with hypertension,heart failure,myocardial ischemia-reperfusion injury,ventricular remodeling,arteriosclerosis and aneurysm.This paper introduces the research progress of β-arrestin2 in the field of cardiovascular disease,and expounds the structure,function,role and related molecular mechanism of β-arrestin2 in inflammatory reaction and cell metabolism,aiming to provide new ideas and methods for the prevention and treatment of cardiovascular diseases.
关键词
β-抑制蛋白2/G蛋白偶联受体/心血管疾病
Key words
β-arrestin2/G protein coupled receptors/cardiovascular disease
维普
万方数据