Research progress of β-arrestin2 in cardiovascular disease
β-arrestin2 is a kind of intracellular protein with multiple biological functions.It can not only negatively regulate GPCR signal pathway by competitively binding to G protein-coupled receptor(GPCR)with G protein,but also participate in regulating multiple signal transduction pathways through G protein independent pathways,which is critical to the stability of cardiovascular system.In addition,the abnormal expression of β-arrestin2 is associated with hypertension,heart failure,myocardial ischemia-reperfusion injury,ventricular remodeling,arteriosclerosis and aneurysm.This paper introduces the research progress of β-arrestin2 in the field of cardiovascular disease,and expounds the structure,function,role and related molecular mechanism of β-arrestin2 in inflammatory reaction and cell metabolism,aiming to provide new ideas and methods for the prevention and treatment of cardiovascular diseases.
β-arrestin2G protein coupled receptorscardiovascular disease
万方数据
维普
