SRSF2 mutation and its research progress in myelodysplastic syndromes
Spliceosomal protein mutation is one of the most common genetic mutations in myelodysplastic syndromes(MDS).Among them,the SRSF2 mutation promotes exon recognition through its N-terminal RNA recognition motif domain(RRM)binding to the mRNA exon splicing enhancer(ESE)motif.This results in the occurrence of abnormal splicing events.SRSF2 mutations can lead to abnormal splicing events,some of which are directly related to the pathogenesis of MDS.Current studies have shown that SRSF2mutation is an adverse prognostic factor for MDS.Therefore,this paper reviews SRSF2mutation and its mechanism of MDS,targeted treatment of MDS patients with SRSF2 mutation,and the impact of SRSF2 mutation on the prognosis of MDS,in order to explore new therapeutic targets.
万方数据
维普
