Effect of tumor microenvironment on chemotherapy resistance in gastric cancer
Gastric cancer is a kind of malignant tumor with high incidence of digestive tract.Chemotherapy resistance is one of the main causes of death.Tumor microenvironment(TME)promotes chemotherapy resistance in gastric cancer through various pathways and mechanisms,so TME may be the key to evaluate tumor development direction and overcome therapeutic resistance.In view of the lack of effective clinical protocols for the treatment of chemotherapy resistance in gastric cancer,this paper reviewed the relationship between cellular and non-cellular components of TME and chemotherapy resistance in gastric cancer cells,as well as the biomarkers and therapeutic targets associated with major components of TME and chemotherapy resistance.In addition,this paper further discussed the mechanism of different cells in TME promoting chemotherapy resistance in gastric cancer,and summarized the potential regulatory factors and drugs,aiming to provide a new perspective for the clinical solution of chemotherapy resistance in gastric cancer,and provide new ideas for the prevention and treatment of gastric cancer.
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