Inflammatory diseases are usually caused by an excessive or persistent inflammatory response.Inflammatory cytokines are involved in several processes in the inflammatory response,such as promoting the aggregation of inflammatory cells and inducing the production of inflammatory mediators.Controlling the production of inflammatory cytokines is therefore crucial to the treatment of inflammatory diseases.Dehydroepiandrosterone(DHEA)is an endogenous steroid hormone.DHEA regulates the production and release of inflammatory cytokines and has the potential to control the inflammatory response.This paper reviews the characteristics of DHEA,the mechanism of regulating inflammatory cytokines and the prospect of clinical application to provide new ideas and strategies for the clinical treatment of inflammatory diseases.
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