Research progress of metagenomic next-generation sequencing in detecting infectious pathogens in patients with haematological malignancies
Metagenomic next-generation sequencing(mNGS)is an emerging pathogen detection method,which can rapidly,uniformly and unbiased sequence all microorganisms in a specimen,thus significantly improving the detection rate of pathogenic microorganisms.Hematological malignancies complicated with infection have high morbidity and mortality,and the types of infection and pathogenic microorganisms are complex and diverse,which bring certain difficulties to clinical diagnosis.mNGS has high clinical diagnostic value for different types of hematological malignancies with infection.This paper reviews the current application status and limitations of mNGS technology in hematological malignancies,in order to promote the better application of this technology in hematological malignancies with infection.
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