Discussion on 3',5'-phosphodiester bonds in DNA/RNA
3',5'-phosphodiester bond is an important term and topic in biology,biochemistry,organic chemistry and other related subjects.However,the understanding of its interpretation and connotation are different in various textbooks,literatures and online platforms at home and abroad,which has been a hot topic of debate for a long time.Based on the basic concepts of groups and chemical bonds,esterification reaction mechanism and influencing factors,structure of phosphoric acid,combined the formation mechanism of 3',5'-phosphate diester bonds,videlicet,the de novo synthesis pathway of nucleotides and the related processes of nucleic acid synthesis,this paper systematically analyzes and explores 3',5'-phosphate diester bonds,clarifies their essence and connotation,and reflects the need for teaching to attach importance to the integration of interdisciplinary knowledge and the cultivation of thinking.
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