The biological functions of chromatin protein kinase VRK1 and the clinical implications as a target in cancer therapy
VRK1(vaccinia-related kinase 1)is a serine-threonine protein kinase generally distributed around nuclear chromatin.It usually doesn't mutate in cancer,but is upregulated in many tumors,which is associated with poor prognosis.In the nucleus,VRK1 can phosphorylate several transcription factors,histones and proteins involved in the DNA damage response,and also participate in acetylation modification of histones during gene transcription.Functionally,VRK1 may regulate cell cycle,mitosis and other processes to promote cell proliferation,and play a critical role in DNA damage repair.In the process of DNA damage,VRK1 regulates histone acetylation to trigger the DNA damage response,and further participates in the non-homologous end-joining DNA repair pathway,and is also related to the p53-mediated DNA damage repair response.Based on the above functions of VRK1,elevated expression of VRK1 in cancer tissues may promote tumor cell proliferation,metastasis,and remain genomic stability.In the studies aiming at cancer therapeutic target,VRK1 can be used as a selective target for cancer synthetic lethal strategies in the prevention and treatment of various cancers.
chromatin protein kinaseproliferationDNA damage repaircancer targets
万方数据
维普
