Application prospect for extracellular vesicles in nonalcoholic steatohepatitis
Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease that is common in the general population.As the disease progresses,patients with simple non-alcoholic fatty liver can develop non-alcoholic steatohepatitis(NASH).Management of NASH becomes a daunting task for clinicians due to lack of clear biomarkers and treatment strategies.Extracellular vesicles(EVs)are heterologous clusters of vesicles produced by the inward or outward budding of the cell membranes,which contain a variety of contents that can regulate cellular metabolic activity,and these contents are involved in disease progression in NASH.In recent years,a growing number of studies have demonstrated the potential of extracellular vesicles for application in NASH.This review will elucidate the role of EVs in NASH and their promising applications in NASH.
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