Long non-coding RNAs(lncRNAs)are a class of non-coding transcripts of more than 200 nucleotides in length.Increasing evidence suggests that lncRNAs play an important regulatory role in the occurrence and progression of cancer.HOXA cluster antisense RNA 2(HOXA-AS2)is a novel lncRNA,which plays an important role in the occurrence and progression of cancer.In this paper,the expression,molecular mechanism and related functions of HOXA-AS2 in a variety of human cancers in recent years were reviewed,and its possible clinical application was discussed.
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