Roles of zinc finger proteins in colorectal cancer
Zinc finger protein(ZNF/ZFP)is a class of transcription factors with finger-like domain,which is widely found in animals,plants and microorganisms.ZNF is expressed in a variety of tumor tissues and participates in the development of tumors by regulating the expression of downstream target genes.Abnormal expression of ZNF is closely related to clinicopathological features and prognosis of colorectal cancer.In this review,the mechanisms of zinc finger protein family members(ZEB1/2,Gli1/3,PLAGL1/2,KLF4,Snail1,ZBTB7A,ZBTB7C,ZBTB16)in colorectal cancer were elaborated from the perspective of four malignant behaviors including proliferation,migration and invasion,apoptosis and stem cancer cells characteristics.This review will provide references for clinical targeted treatment of colorectal cancer.
万方数据
维普
