摘要
锌指蛋白(zinc finger protein,ZNF/ZFP)是一类具有手指状结构域的转录因子,广泛存在于动、植物及微生物体内.ZNF在多种肿瘤组织中表达,通过调控下游靶基因的表达参与肿瘤的发生发展过程.ZNF表达异常与结直肠癌临床病理特征和预后密切相关.本文从结直肠癌的增殖、迁移和侵袭、凋亡、癌细胞干性等4种恶性行为角度,阐述了近年来锌指蛋白家族成员(ZEB1/2、Gli1/3、PLAGL1/2、KLF4、Snail1、ZBTB7A、ZBTB7C、ZBTB16)在结直肠癌中的作用机制,旨在为临床靶向治疗结直肠癌提供参考依据.
Abstract
Zinc finger protein(ZNF/ZFP)is a class of transcription factors with finger-like domain,which is widely found in animals,plants and microorganisms.ZNF is expressed in a variety of tumor tissues and participates in the development of tumors by regulating the expression of downstream target genes.Abnormal expression of ZNF is closely related to clinicopathological features and prognosis of colorectal cancer.In this review,the mechanisms of zinc finger protein family members(ZEB1/2,Gli1/3,PLAGL1/2,KLF4,Snail1,ZBTB7A,ZBTB7C,ZBTB16)in colorectal cancer were elaborated from the perspective of four malignant behaviors including proliferation,migration and invasion,apoptosis and stem cancer cells characteristics.This review will provide references for clinical targeted treatment of colorectal cancer.
基金项目
海南省自然科学基金高层次人才项目(820RC632)
海南省自然科学基金高层次人才项目(2019RC203)
海南省教育厅科学研究项目(Hnky2020-34)
海南医学院大学生创新创业训练计划项目(X202011810128)
海南医学院大学生创新创业训练计划项目(202011810005)
维普
万方数据