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海洋生物毒素的损伤机制

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海洋生物毒素来源于有毒海洋生物,是一类具有高活性的特殊代谢成分.独特新颖的化学结构造就了其对生物体特殊的损伤机制和剧烈的毒性效应.目前,海洋生物毒素损伤机制的研究特别是靶向离子通道方面已经取得了一定的成果,但仍有许多机制尚不清楚.因此,进一步探索海洋生物毒素的损伤机制十分必要,既有助于防治海洋毒素中毒,又有望将其转化为新型"海洋药物".本文综述了目前已有报道的海洋生物毒素对生物的损伤机制,包括直接影响细胞膜各类离子通道活性、干扰胞内蛋白磷酸化过程、扰乱线粒体功能、诱发炎症免疫反应,甚至造成细胞死亡等,为后续深入研究海洋生物毒素的其他损伤机制提供参考.
Damage mechanism of marine biotoxins
Marine biotoxins are a type of highly active special metabolic component that originates from toxic marine organisms.Its unique and novel chemical structure has resulted in its special damage mechanism to organisms and severe toxic effects.Although some progress has been made in the study of the mechanisms underlying marine biotoxin-induced damage,particularly with regard to ion channels,there are still many mechanisms that remain unclear.Therefore,further exploration of the mechanisms underlying marine biotoxin-induced damage is essential.This will not only help to prevent marine biotoxin poisoning but also have the potential to transform these toxins into new"marine drugs".This article provides an overview of the reported mechanisms of marine biotoxin toxicity,including their direct effects on various ion channels on cell membranes,interfering with the intracellular protein phosphorylation process,disrupting mitochondrial functions,inducing inflammatory and immune responses,and even causing cell death,which can serve as a reference for future in-depth research.

marine biotoxinsdamage mechanismion channelprotein phosphorylationmitochondrial function

李金倩、尚欣瑞、彭蕾、樊哲哲、马裕清、黄宁、孙铭娟

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海军军医大学基础医学院学员四大队,上海 200433

海军军医大学基础医学院学员三大队,上海 200433

海军军医大学基础医学院生物化学与分子生物学教研室,上海 200433

海洋生物毒素 损伤机制 离子通道 蛋白磷酸化 线粒体功能

国家自然科学基金国家重点研发计划项目

821737322019YFC0312603

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(11)
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