Relationship between intestinal flora and acute lung injury/acute respiratory distress syndrome
Intestinal tract and lung share some similarities in mucosal structure,physiological and immune function.When the flora in the gastrointestinal and respiratory mucosa is disturbed,it affects the development and prognosis of intestinal diseases and acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Intestinal dysbiosis may induce intestinal inflammatory diseases,stimulate intestinal immune response and increase the permeability of the intestinal mucosal epithelium.With the help of the gut-lung axis or other pathways,bacteria and inflammatory factors will contribute to the development of lung disease,resulting in ischemia and hypoxia in tissues and organs,which ultimately hinders prognosis in a range of lung diseases.This review will focus on the relationship between intestinal dysbiosis and ALI/ARDS,emphasizing the chronic inflammation in the gut and lung caused by intestinal dysbiosis,providing new ideas on the causes of lung diseases triggered by intestinal dysbiosis and its underlying mechanisms,and providing new clues for subsequent treatment.
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维普
