Research progress of osteoporosis in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease(COPD)is a common respiratory disease,which mainly occurs in the middle-aged and elderly people.It often has many extrapulmonary complications,such as cardiovascular disease,osteoporosis,diabetes,metabolic syndrome and so on.Long-term smoking,lack of exercise and inhalation of harmful gases are the main risk factors for COPD.Glucocorticoids are the main treatment method,and long-term use of glucocorticoids can lead to the occurrence of osteoporosis.The characteristics of osteoporosis are low bone mass and deterioration of bone tissue microstructure,leading to an increase in bone fragility,thereby increasing the risk of fracture.Fractures caused by osteoporosis may increase the incidence rate and mortality of COPD patients,and lead to further deterioration of lung function.Therefore,COPD is closely related to osteoporosis,and to some extent,they are mutually causal.The high incidence of osteoporosis in COPD patients is believed to be caused by common risk factors such as older age and smoking,as well as specific risk factors for COPD such as systemic inflammation,glucocorticoid use,and vitamin D deficiency.At present,the treatment of COPD patients in clinical practice mostly neglects the treatment of their combined osteoporosis,and the pathological mechanism of COPD combined osteoporosis still needs further research.Therefore,this paper reviews the pathogenesis,risk factors,and treatment of COPD combined with osteoporosis,in order to provide new directions for the treatment of COPD combined with osteoporosis patients.
chronic obstructive pulmonary diseaseosteoporosisbone density
万方数据
维普
