Histone lactylation is a novel post-translational modification mediated by lactic acid,which plays a role in various pathophysiological processes,including inflammation,fibrosis and pro-angiogenesis.It is closely associated with neurological,respiratory,and reproductive disorders and is potential drug targets.This paper briefly introduces the biological functions of histone lactylation and its roles in non-tumor diseases.These findings may offer novel ideas for the treatment and intervention of related diseases and provide insights into the functions and mechanisms of histone lactylation.
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