首页|PM2.5影响2型糖尿病分子机制的研究进展

PM2.5影响2型糖尿病分子机制的研究进展

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大气PM2.5污染暴露可对人体健康产生多种不良影响,其中,促进糖尿病发生发展是其影响健康的重要途径.本文继细述了PM2.5主要通过氧化应激、炎症反应、线粒体功能障碍、内质网应激等分子机制影响2型糖尿病发生发展之后,探讨了铁死亡可能参与PM2.5致2型糖尿病发生发展的进程,并指出了深入研究PM2.5致2型糖尿病发生发展机制的紧迫性,以期为相关部门的科学决策和为新学者提供基础科学资料.
Research progress on molecular mechanism of PM2.5 affecting type 2 diabetes
Exposure of atmospheric PM2.5 pollution has a variety of adverse effects on human health,among which promoting the occurrence and development of diabetes is an important way to affect health.In this review,after elaborating that PM2.5 affects the occurrence and development of type 2 diabetes mainly through molecular mechanisms,such as oxidative stress,inflammatory reaction,mitochondrial dysfunction and endoplasmic reticulum stress,we have also discussed that ferroptosis might participate in the process of the occurrence and development of type 2 diabetes caused by PM2.5 exposure,and pointed out that it was urgent to further study the underlying molecular mechanisms of the occurrence and development of type 2 diabetes caused by PM2.5.The aim is to provide basic scientific information for both scientific decision-making of the relevant departments and newcomers in this researching field.

PM2.5T2DMoxidative stressinflammatory responseferroptosis

张钰棋、张瑛、曹运长、王五香、封少龙

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桂林医学院公共卫生学院,广西环境暴露组学与全生命周期健康重点实验室/预防医学研究所,桂林 541199

桂林医学院智能医学与生物技术学院,桂林 541199

南华大学图书馆,衡阳 421001

中国科学院广州地球化学研究所有机地球化学国家重点实验室,广州 510640

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PM2.5 2型糖尿病 氧化应激 炎症反应 铁死亡

国家自然科学基金有机地球化学国家重点实验室开放基金

41877390SKLOG-202213

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(12)
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