Association between obstructive sleep apnea hypopnea syndrome and non-alcoholic fatty liver disease
The complications of obstructive sleep apnea hypopnea syndrome(OSAHS)involve multiple systems and organs,among which the digestive system is often closely related to nonalcoholic fatty liver disease(NAFLD).Although obesity is an important risk factor in both OSAHS and NAFLD,studies have shown that OSAHS is associated with the development and evolution of NAFLD even in the absence of obesity or other shared risk factors.The OSAHS-NAFLD association is related to the degree of intermittent hypoxia(IH)as a result of recurrent episodes of upper airway obstruction during sleep in OSAHS.This work discusses the association between OSAHS and NAFLD and its related mechanisms,focusing on the role of IH in the progression of NAFLD.