Research progress of bisphenol A promoting polycystic ovary syndrome based on metabolic regulation
Bisphenol A(BPA)is a typical and widespread endocrine disrupting chemicals(EDCs)in daily life,which can cause reproductive and metabolic abnormalities in humans.The association between BPA and endocrine disorders has been suggested.Polycystic ovary syndrome(PCOS)is the most common endocrine disorder among women of reproductive age.It has been found that BPA induces reproductive and metabolic abnormalities similar to those characteristics of PCOS,so it is hypothesized that there is a correlation between BPA and PCOS and BPA may be an influential factor in the pathogenesis of PCOS.This work reviews the relationship between BPA and steroid hormones,insulin resistance,lipid metabolism,and inflammation to elucidate the ways in which BPA affects steroid hormone secretion,causes insulin resistance,and other PCOS-related reproductive metabolic disorders,respectively,and thus to explore the relationship between BPA and PCOS.
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