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功能代谢组学在急性肾损伤中的作用

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急性肾损伤(acute kidney injury,AKI)是由多因素引起的肾功能急速下降的临床综合征.AKI发病机制复杂,且在临床上缺乏有效的治疗手段.近年来,功能代谢组学探究AKI的发病机制已成为新的研究热点,与传统代谢组学不同,功能代谢组学可在疾病发现差异代谢物基础上,明确阐明疾病发生的病理生理机制.本文结合近几年研究成果,总结了代谢组学几大分支在AKI中的研究进展,重点探讨了各代谢物调控分子通路变化,以期为AKI的早期预防及治疗提供理论依据.
Roles in functional metabolomics in acute kidney injury
Acute kidney injury(AKI)is a clinical syndrome of rapid decline in renal function caused by multiple factors.There aren't many effective treatments available in clinical practice,and its pathophysiology is complicated.In recent years,functional metabolomics has become a new research focus to explore the pathogenesis of AKI.Functional metabolomics,in contrast to standard metabolomics,uses the identification of distinct metabolites in disease to clearly define the pathophysiological process of disease occurrence.In order to provide a theoretical foundation for the early prevention and treatment of AKI,this study highlights the scientific development of many areas of metabolomics in AKI,focusing on modifications of metabolite regulating molecular pathways.

acute kidney injuryfunctional metabolomicsglucose metabolismlipid metabolism amino acid metabolismnucleotide metabolism

李惠敏、朱杰夫、胡斌、宋志霞

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三峡大学第一临床医学院,宜昌市中心人民医院,宜昌 443000

武汉大学人民医院器官移植科,武汉 430000

三峡大学附属仁和医院肾内科,宜昌 443000

急性肾损伤 功能代谢组学 糖代谢 脂代谢 氨基酸代谢 核苷酸代谢

湖北省自然科学基金宜昌市医疗卫生项目专项基金

2021CFB379A21-2-002

2023

生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
年,卷(期):2023.43(12)
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