Membranous nephropathy(MN)is an immune-mediated kidney disease characterized by subepithelial immune deposition.At present,through the use of advanced proteomics techniques,a variety of target antigens have been identified.Antigen-associated MN may show unique clinical and pathological associations,which can helps physicians to identify potential causes and triggers,such as autoimmune diseases,cancers,drugs and infections.Antigen-based approaches will further define subtypes of MN and will be expected to facilitate the development of non-invasive diagnostic methods.Therefore,this work provides a reviews of recent research on MN antigens,histopathology,and pathogenesis.
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