Renal tubular atrophy and tubulointerstitial fibrosis are common pathologic manifestations of chronic kidney disease(CKD).Biomarkers of renal tubular injury usually reflect the process of direct tissue injury and repair in the renal tubular interstitium,and their severity has been shown to be a reliable indication for predicting disease progression.Most studies use glomerular filtration rate and urine albumin/creatinine ratio as the main indicators for assessing CKD.However,diagnostic markers of renal tubular injury have not been studied clearly in chronic kidney disease.Therefore,this paper provides the research progress of renal tubular injury diagnostic markers in CKD,with the aim of maximizing the diagnosis,treatment and prevention of CKD and providing more comprehensive assessment of kidney health.
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