The mechanism of hypoxia-inducible factor in the progression of chronic kidney disease to end-stage renal disease
Chronic kidney disease(CKD)has become a global health challenge,and delaying its progression to end-stage renal disease(ESRD)is an important goal for our treatment of CKD.Hypoxia and hypoxia inducible factor(HIF)are closely related to the occurrence and development of CKD.The increase in HIF expression can delay the process of CKD and reduce the occurrence of CKD complications.This review mainly discusses the role of HIF in CKD anemia,renal interstitial fibrosis,inflammation,vascular calcification,and acute kidney injury,aiming to provide new targets and ideas for delaying the progression of CKD to the ESRD stage and improving the prognosis of CKD patients.
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维普
