生命的化学2023,Vol.43Issue(12) :1941-1948.DOI:10.13488/j.smhx.20230217

姜黄素防治肾脏疾病的机制研究进展

Research progress on the mechanism of curcumin in prevention and treatment of kidney diseases

汪松 陈林 何江枢 李嘉 龙军 杨进
生命的化学2023,Vol.43Issue(12) :1941-1948.DOI:10.13488/j.smhx.20230217

姜黄素防治肾脏疾病的机制研究进展

Research progress on the mechanism of curcumin in prevention and treatment of kidney diseases

汪松 1陈林 1何江枢 2李嘉 1龙军 1杨进2
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作者信息

  • 1. 遵义医科大学研究生院,遵义 563000;成都大学附属医院泌尿外科,成都 610081
  • 2. 成都大学附属医院泌尿外科,成都 610081
  • 折叠

摘要

姜黄素(curcumin)是提取于植物中的酮类天然化合物,具有抗炎、抗氧化、抗癌等作用.因其具有不良反应少、作用靶点广泛等优点,在各种肾脏疾病如肾炎、急/慢性肾损伤、肾纤维化等中发挥保护作用,并具有改善药物或有毒物质引起的肾脏损伤、减轻化疗药物对肾脏的损害和协同放化疗抗肾脏肿瘤的作用,近年来已成为肾脏疾病治疗的研究焦点,然而其潜在的作用机制及治疗作用以及后续的临床应用仍需进一步总结和探索.本文从病理生理的角度出发,系统综述了姜黄素在各种肾脏疾病中的作用及其潜在的机制,为后续的研究以及临床应用提供线索和依据.

Abstract

Curcumin is a natural ketone compound extracted from plants,has anti-inflammatory,antioxidant and anticancer effects.Due to its advantages of few side effects and wide range of targets,it plays a protective role in a variety of kidney diseases such as nephritis,acute/chronic kidney injury and renal fibrosis,and has the effect of improve kidney damage caused by drugs or toxic substances,alleviating the damage of chemotherapy drugs to the kidney and synergistic chemoradiotherapy to play the role of anti-renal tumor.In recent years,it has become the focus of research on the treatment of kidney diseases.However,its potential mechanism of action,therapeutic effect and subsequent clinical application still need to be further summarized and explored.From the perspective of pathophysiology,this paper systematically reviewed the role and potential mechanism of curcumin in various renal diseases,providing clues and basis for subsequent research and clinical application.

关键词

姜黄素/肾脏疾病/治疗作用/分子机制

Key words

curcumin/renal disease/therapeutic effect/molecular mechanism

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基金项目

国家自然科学基金(81500577)

四川省科技厅自然科学基金(2022NSFSC1592)

出版年

2023
生命的化学
中国生物化学与分子生物学会

生命的化学

CSTPCD
影响因子:0.404
ISSN:1000-1336
参考文献量1
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