Progress in development of microbial reduced genome
Research on microbial reduced genome is a key focus of synthetic biology. An engineering cell with reduced genome and robust, predictable, controllable physiological traits could be built by rational design and gene manipulation, which could serve as a desired chassis cell for biotechnological applications. In this paper, the research strategies, empirical methods for genome reduction and related research progress of some model microorganisms were reviewed. The difficult problems and solutions when constructing the reduced genome cell, as well as application prospects of the reduced genome cell were discussed.
NETL
NSTL
万方数据
维普
