Advances in the research of MCP-1-induced protein-1
MCP-1-induced protein-1 (MCPIP 1) is a newly identified CCCH zinc finger protein that is induced in human monocyte-derived macrophages when stimulated by monocyte chemotactic protein (MCP-1) or IL-1β.MCPIP1 plays a key role in the down-regulation of inflammatory cytokines such as IL-6 and IL-12p40.The underlying mechanism that MCPIP1 negatively regulates inflammatory factors has been studied at different levels.MCPIP1 is an essential RNase and down-regulates specific mRNAs of cytokines via a conserved region in the nonAU-rich element of the 3'-UTR.Furthermore,MCPIP1 acts as a deubiquitinase to negatively regulate JNK and NFκB signaling by targeting the TNF receptor-associated factors (TRAFs).In this review,we summarized recent research progress and discussed the structure,biological function,regulation and mechanism of MCPIP 1,as well as its clinical application potential.
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