Research progress and prospects of mRNA modification
Nucleotide modifications of messenger RNA include 2'-O-methylation,pseudouridylation,m6A,m5C,m7G,m1A,5hmC,etc.Previous studies have shown that these modifications play an important role in mRNA stability,processing,transmission of genetic information and cellular stress response.As a result of the limitation of technology,we know very little for mRNA modification in the past.Recently,a series of new technology provide great convenience for comprehensive inspection and further biological function research of mRNA nucleotide modification and have already made some important progress.This review introduced the research progress and prospects of mRNA modification.
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NSTL
万方数据
维普
