Gene therapy refers to a biomedical means of treating diseases by manipulating or modifying the expression of cellular genes at the gene level.In recent years,with more products continuing to be approved,it has become a new hot track in the field of biomedicine after small molecules and macromolecules.This article analyses the development trend and progress of gene therapy in 2023 in terms of basic research,clinical research and product approval.The analysis found that the emergence of new technologies,as well as the deepening understanding of disease biology has pushed gene therapy into a new era,broadened the therapeutic scope of gene therapy,and accelerated the development of products.In 2023,a number of breakthrough new products of gene replacement therapy,gene editing therapy and RNA therapy have been launched.Significant progress has been achieved in the development and optimization of delivery technologies.Meanwhile,the potential risks and effectiveness of gene therapy still require further long-term tracking research.And accessibility of gene therapy also needs to be further improved by exploring multiple pathways.Finally,this paper also looks forward to the future development of the gene therapy.