Progress in exercise-induced vascular adaptation and its hemodynamic mechanism
Physical activity is one of the most crucial factors influencing the human vascular system.The structure and function of blood arteries are directly impacted by exercise-induced hemodynamic stimulation.According to studies,exercise training causes quick alterations in artery function,which are thereafter overtaken by vascular remodeling.However,it is still unknown what causes the time course of functional and structural vascular adaptations.Shear stress and circumferential stress are the main hemodynamic stimuli generated by exercise.Vascular endothelial cells and smooth muscle cells have the ability to transform mechanical inputs into chemical signals,which can then affect ion channels,alter transcription factors and the activation of relevant genes,and lead to adaptive modifications.This paper reviews the adaptation of vascular structure and function to exercise and its hemodynamic mechanisms based on vascular structure and function to provide new ideas and strategies for preventing and treating vascular diseases.
exercisehemodynamic stimulivascular adaptationvascular structurevascular function
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