Research progress of catechins inhibiting cell death induced by cerebral ischemia/reperfusion
Cerebral ischemia/reperfusion(I/R)is most commonly observed following the restoration of blood flow after ischemic stroke and during cardiac arrest/cardiopulmonary resuscitation(CA/CPR).Under the pathological conditions of reperfusion,functional damage ultimately results in cell death in the brain.Extensive research has demonstrated that cerebral I/R induces various forms of cell death,including apoptosis,pyroptosis,autophagy,necroptosis,and ferroptosis.Investigating these cell death mechanisms can unveil the underlying pathological processes of cerebral I/R injury,providing valuable insights for identifying therapeutic targets to improve neurological function.Catechins,as antioxidants,have the ability to suppress cell death induced by oxidative stress.The presence of diverse forms of cell death in cerebral I/R highlights the heterogeneous nature of its pathological mechanisms.Therefore,in this review we aim to summarize and identify the patterns of these mechanisms,offering new perspectives for the development of treatments for cerebral I/R injury in both basic and clinical research.
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