The role of eIF4A in cap-and IRES-dependent translation initiation
In biological systems,there are two primary translation initiation mechanisms:cap-dependent translation initiation and internal ribosome entry sites(IRES)-mediated translation initiation.Cap-dependent translation initiation is the classical model in eukaryotic organisms,while most positive-strand RNA viruses employ an IRES-dependent translation mechanism.The eukaryotic initiation factor 4A(eIF4A),a member of the DEAD-box RNA helicase family,features RNA-dependent ATPase and RNA helicase activities,yet the specific unwinding mechanism of eIF4A remains unclear.Additionally,eIF4A engages in complex and close interactions with other eukaryotic initiation factors,playing a key role in both cap-dependent and IRES-mediated translation initiation processes.This article primarily reviews the functions and structures of eIF4A,and the mechanisms of eIF4A in cap-dependent and IRES-mediated translation initiation.
NETL
NSTL
万方数据
维普
