The role of HIF1α and GLP-1 in chrono-exercise regulating glucose homeostasis
Daily blood glucose changes in the organism have a biological rhythm.Chrono-exercise is a method of choosing exercise time for physical exercise based on the organism's biological rhythm.Recent studies have found that different exercise times have different effects on the regulation of glucose metabolism.However,the regulatory mechanism has not been elucidated.This review took the"exercise timing effect"as an entry point,and summarized the different intervention effects of morning/evening exercise,pre/postprandial exercise,and exercise sequences of different exercise modalities on glucose homeostasis,with a focus on the mechanism of glucose homeostasis regulation by chrono-exercise.In particular,chrono-exercise may mediate the"exercise timing effect"through hypoxia inducible factor 1α(HIF1α)and glucagon-like peptide-1(GLP-1),thus regulating glucose homeostasis,with a view to provide reference for subsequent studies.
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万方数据
维普
