Research progress of N6-methyladenine modifications in breast cancer
Epigenetics plays important role in regulating the malignant progress of breast cancer,where N6-methyladenine(m6A)is the richest modification of RNA,taking part in many signaling pathways and influencing the tumor microenvironment.Breast cancer is the most common malignant tumors in Chinese women,which has a good prognosis after treatment at an early stage but a low five-year survival rate when metastasis occurs.As a new biomarker of screening breast cancer at early stage and a possible medicine target,m6A provides multiple ideas for the development of early treatment of breast cancer.This paper systematically reviews regulatory functions of m6A-related molecules in different malignant behaviors,and additionally list some target drugs and possible measures to screen breast cancer,providing new ideas to diagnosis,treat and monitor breast cancer.
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