Review on the molecular,cellular and circuit-level mechanisms of sleep-wake regulation
Sleep is an important contributing factor for human health,sleep disorders are prone to cause a variety of physiological and psychological diseases.Sleep homeostasis is influenced by both external factors(circadian rhythm,diet and temperature)and intrinsic systems(molecular clock and sleep/wake prompting neurons).Within the cell,intracellular molecules such as CLOCK,PER,CRY,NPAS2 and BMAL1 modulate circadian rhythm.Secondly,neuronal assemblies in the basal forebrain,thalamus,hypothalamus,pons,and medulla oblongata specifically inhibit or initiate sleep and wakefulness;neuronal assemblies connect with synaptic connections that specifically regulate the initiation and maintenance of wakefulness,non-rapid eye movement sleep and rapid eye movement sleep.Sleep disorders are commonly existed in people with irregular lifestyles.In this review,we discuss the molecular,cellular and neural circuit mechanisms underlying sleep-wakefulness regulation,which will provide new insights for sleep-disorder diseases.
sleepwakebrain networkcircadian rhythmrapid eye movement sleep
NETL
NSTL
万方数据
维普
