摘要
睡眠是影响人体健康的重要因素,睡眠失调易引起多种生理和心理疾病.睡眠稳态既受外界因素(昼夜变化、饮食和温度)影响,亦受内在系统(分子钟和促睡眠/觉醒神经元)调控.细胞内有CLOCK、PER、CRY、NPAS2和BMAL1等分子周期性变化控制生物节律;脑内有基底前脑、丘脑、下丘脑、脑桥和延髓等神经元群体特异性地抑制或促进睡眠与觉醒,各核团之间通过突触连接形成神经网络启动和维持觉醒、非快速眼动睡眠和快速眼动睡眠.睡眠障碍普遍存在,本综述将针对调控生物体睡眠-觉醒的分子、细胞和脑网络机制展开讨论,为防治睡眠障碍类疾病提供新的思路.
Abstract
Sleep is an important contributing factor for human health,sleep disorders are prone to cause a variety of physiological and psychological diseases.Sleep homeostasis is influenced by both external factors(circadian rhythm,diet and temperature)and intrinsic systems(molecular clock and sleep/wake prompting neurons).Within the cell,intracellular molecules such as CLOCK,PER,CRY,NPAS2 and BMAL1 modulate circadian rhythm.Secondly,neuronal assemblies in the basal forebrain,thalamus,hypothalamus,pons,and medulla oblongata specifically inhibit or initiate sleep and wakefulness;neuronal assemblies connect with synaptic connections that specifically regulate the initiation and maintenance of wakefulness,non-rapid eye movement sleep and rapid eye movement sleep.Sleep disorders are commonly existed in people with irregular lifestyles.In this review,we discuss the molecular,cellular and neural circuit mechanisms underlying sleep-wakefulness regulation,which will provide new insights for sleep-disorder diseases.
基金项目
武汉科技大学大学生创新创业训练计划项目(22Z106)
职业危害识别与控制湖北省重点实验室开放基金项目(0HIC2021Z07)
国家自然科学基金青年项目(82201351)
NETL
NSTL
维普
万方数据