Advances in genetically engineered bacteria-based drug delivery systems for precision medicine
The human body harbors a vast array of symbiotic microorganisms on both its external and internal surfaces,and the interplay between microbial communities and the onset and progression of human diseases is intricately intertwined.With the advancement of synthetic biology,the utilization of drug delivery system based on genetically engineered bacteria has emerged as a catalyst for the exploration of microbe-host interactions and disease treatment.Genetically engineered microbes refer to microorganisms that have undergone genetic modifications,endowing them with the ability to efficiently produce desired products.By designing therapeutic targets and drug delivery gene circuits,genetically engineered microbes can achieve precision drug delivery to specific sites such as the intestinal tract or tumors.This paper provides a comprehensive review of three pivotal features associated with genetically engineered bacteria-based drug delivery systems:therapeutic molecules,delivery mechanisms,and intelligent response systems.Challenges encountered in clinical applications are discussed,and the future prospects of genetically engineered living drugs are contemplated.
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