Research progress of trispecific antibodies in tumor immunotherapy
Trispecific antibodies(TsAbs)are innovative therapies that target three different antigen-binding sites on tumor cells or immune effector cells simultaneously.Compared with monoclonal antibodies and bispecific antibodies,TsAbs can increase binding specificity and reduce off-target toxicity,offering broad application prospects in the field of tumor immunotherapy.In this paper,we introduce the development process,main construction forms,and mechanism of action of TsAbs.Furthermore,we summarize the latest research progress on representative drugs with different target combinations.Finally,we discuss the challenges and future development directions of TsAbs,aiming to provide new ideas for the development of trispecific antibody drugs.
NETL
NSTL
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