Cellular prion protein(PrPC)is a highly conserved cell surface glycoprotein with multiple ligands and is expressed in many tissues and cell subtypes to varying degrees,and is highly expressed in the central nervous system(CNS).Studies have found that PrPC can alleviate ischemic brain injury by reducing excitatory toxicity,inflammatory response,oxidative stress,apoptosis,and promoting nerve regeneration and angiogenesis.Therefore,this review aims to provide an overview of the fundamental knowledge of PrPC,its physiological and pathological functions,and the mechanisms by which it exerts its effects on the brain in ischemic conditions.This information is essential for the development of effective strategies for the prevention and treatment of ischemic brain injury.
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