Research progress on immunoinflammatory responses related to the development of Alzheimer's disease
Alzheimer's disease(AD)is a chronic neurodegenerative disease characterized by intracellular neurofibrillary tangles and extracellular amyloid plaques.There is increasing evidence that inflammatory responses,including neuroinflammation,may play an important role in the pathogenesis of AD.Various cytokines released by the body's immune cells after sensing external stimuli are the key factors in inducing inflammation and early symptoms of AD.Neuroinflammation eventually leads to neurodegeneration and AD.In this paper,we summarize the mechanism of certain immune cells such as microglia,macrophages,monocytes and neutrophils involving in the development of the initial pathological features of AD during the development of AD,and further explore the role of different immune cells in the occurrence and development of AD,so as to deepen our understanding of the relationship between the innate immune system and the pathogenesis of AD.
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