Advances in regulatory roles and mechanisms of microglia in autism spectrum disorders
Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in social communication and restricted or repetitive behaviors.Neurological and immune system dysfunctions are considered to be fundamental causes of ASD.Studies have shown that microglia,the brain's resident immune cells,are a possible key player in ASD.Therefore,the relationship between microglia dysfunction and ASD is worth further exploration.This review mainly discusses the role of microglia in neurodevelopment,analyzes the neuroregulatory role of microglia in ASD,summarizes the current studies on targeting microglia to alleviate ASD,and provides theoretical basis and potential targets for therapeutic intervention of ASD.
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