Research progress on refractory wounds of diabetes mellitus
Diabetic wounds are characterized by high morbidity,difficulty in repair,and delayed healing,which seriously affect the quality of life of patients and threaten human health.After the hemostatic phase,diabetic wounds tend to have delayed regression of the inflammatory phase and increased oxidative stress,resulting in delayed wound healing.This review introduces the concept of diabetic wound healing and the latest research progress on wound tissues,cells,neuropathy,and wound microbiota in the process of diabetic wound healing,and describes the factors and mechanisms affecting diabetic wound healing from the levels of wound microenvironment,cell function,cytokines,and molecules,with the aim of providing a new point of entry for the diagnosis and treatment of diabetic wounds.
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