Introduction of protein degradation technologies in Caenorhabditis elegans
Protein degradation is an important process in organisms,which involves the regulation of protein structure and function.The specific protein degradation tags can be used to study the physiological functions of target protein.In this article we mainly introduce various protein degradation techniques and their applications in the model organism Caenorhabditis elegans.We elaborate on the working principle,advantages and disadvantages of the auxin-induced degradation system,and further describe its derived systems and improving strategies in detail.In comparison,we introduce other protein degradation strategies,such as the ZF1/ZIF-1 degradation system,the GFP antibody degradation system,the light-induced degradation system and the drug-induced degradation system,and briefly analyze and discuss the advantages and disadvantages of these systems.The protein degradation technologies help us not only understand the biological processes,but also discover new disease treatment strategies,which will play a significant role in understanding the life activities and diseases prevention.
protein degradationCaenorhabditis elegansauxin-inducible degradationdegradation tag
NETL
NSTL
万方数据
